Primary Immunodeficiencies Caused by Defects of Cytokines and Cytokine Receptors

The immune system responds to antigenic stimulation with a complex array of molecular events involving antigen-presenting cells, B-cells, T-cells, and phagocytes. Cytokines and their respective receptors are intimately involved in regulating such immune responses. Their pivotal role can be illustrated in animal models for which certain cytokines or their receptors have been deleted.