CD7分子

CD7 分子   CD7 常用单克隆抗体或代号：3A1，Leu9 主要表达细胞：T，NK，不成熟Mysub[T] 分子质量(kDa)和结构：gp40(IgSF) 功    能：T、NK细胞活化   CD7 Membrane glycoprotein and Fc receptor for IgM Homologous to TCR gamma, Ig kappa Membrane expression early during T ontogeny, before TCR rearrangement, persists until terminal stages of T cell development Lower expression in memory T cells vs. naive T cells Positive staining (normal): mature peripheral T cells (85%), post-thymic T cells (majority), NK cells (majority), some myeloid cells Positive staining (disease): T cell ALL; AML (especially M4/M5), chronic myelogenous leukemia, blasts in transient myeloproliferative disorder Negative expression: B cell ALL, Sezary syndrome, adult T cell leukemia/lymphoma Micro images: extranodal NK/T cell lymphoma, nasal type