CD73分子

CD73 分子   CD73 常用单克隆抗体或代号： 7G2.2.11,AD- 2 主要表达细胞： Bsub,Tsub,En [B] 分子质量(kDa)和结构： p69(GPI连接） 功    能： 5’-核苷酸外切酶,T细胞活化   CD73 Aka ecto-5-nucleotidase, PI-linked Catalyses dephosphorylation of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to their corresponding nucleosides Mediates costimulatory signals in T cell activation, lymphocyte adhesion to endothelium May be lymphocyte maturation marker High levels are poor prognostic factors in leukemia/lymphomas Positive staining (normal): B and T cell subset; endothelial cells, on follicular dendritic cells, epithelial cells Positive staining (disease): acute T cell leukemia, CLL, ALL