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Instrumentation, Accuracy, and Quality Control Issues in Development of Quantitative Fluorescence-Im
Many fundamental questions of biology reduce to a common technical problem, how
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Fluorescence In Situ Hybridization (FISH) as a Tool for the Detection of Significant Chromosomal Abn
Cytogenetics is integral to the diagnosis of childhood leukaemia, particularly i
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Feeder Layers: Co-culture with Nonneoplastic Cells
Maintenance of a mitotically inactive feeder layer which is able to provide extr
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Evolution of Cytogenetic Methods in the Study of Cancer
Cytogenetic methods have not changed greatly over the last 50 years since Nowell
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Oncolytic Viral Therapy Using Reovirus
Current mainstays in cancer treatment such as chemotherapy, radiation therapy, h
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The Mammalian Two-Hybrid Assay for Detection of Coactivator-Nuclear Receptor Interactions
The two-hybrid assay was described in 1989 as a method to determine protein-prot
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Manual Microdissection Combined with Antisense RNALongSAGE for the Analysis of Limited Cell Numbers
Establishing a gene expression profile of defined subtypes of cells within an or
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Methods to Study p53-Repressed Promoters
There is substantial evidence in the literature that, in addition to functioning
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Molecular-Targeted Therapy for Cancer and Nanotechnology
In order to stop malignant tumor growth, >90% of a critical biochemical pathw
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Adenovirus-Mediated Wild-Type p53 Gene Transfer into Head and Neck Cancers
Mutation of the p53 tumor-suppressor gene is recognized as one of the most commo
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Assaying for BRAF V600E in Tissue and Blood in Melanoma
The BrafV600E mutation has been detected in patients with metastatic melanoma, c
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Assays for Neoplastic Cell Enrichment in Bone Marrow Samples
Most hematological malignancies have clonal cells that reside in the bone marrow
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Development of Drug-Resistant Models
The observation that tumors are capable of developing resistance to anticancer a
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Modeling Pancreatic Cancer in Animals to Address Specific Hypotheses
Multiple experimental approaches have been employed to study exocrine pancreatic
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Introduction
Like most cytogeneticists, I have been informed by well-meaning colleagues at re
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