-
Genetic Suppressor Elements in the Characterization and Identification of Tumor Suppressor Genes
The subject of the present chapter is the genetic suppressor element (GSE) metho
2025-03-15 13 -
Direction of the Recognition Specificity of Cytotoxic T Cells Toward Tumor Cells by Transduced, Chim
Cellular transformation does not necessarily require the expression of proteins
2025-03-15 10 -
Transactivation and Transrepression Studies with p53
The methods outlined in this chapter are designed to facilitate the study of the
2025-03-15 12 -
Energy Intake, Physical Activity, Energy Balance, and Cancer: Epidemiologic Evidence
Energy intake, physical activity, and obesity are modifiable lifestyle factors.
2025-03-15 14 -
Lymphoid Disorders Other than Common Acute Lymphoblastic Leukemia: Background
This chapter describes the background to cytogenetic studies in lymphoid disorde
2025-03-15 13 -
MicroRNA Profiling in Ovarian Cancer
The evaluation of microRNA profiles has represented one of the first approaches
2025-03-15 12 -
PTEN and Cancer
Genetic evidence strongly suggested that a tumor suppressor was located on chrom
2025-03-15 14 -
Isolation and Culture of Leukemia Cell Lines
The availability of continuous human leukemia cell lines as a rich resource of a
2025-03-15 9 -
TP53, hChk2, and the Li-Fraumeni Syndrome
In 1969 Li and Fraumeni (1 ,2 ) reported a systematic epidemiologic study of the
2025-03-15 10 -
Caspase Activity Assays
Caspase activity assays in multi-well plate formats represent powerful tools for
2025-03-15 13 -
Selection of Cytochrome P450 Genes for Use in Prodrug Activation-Based Cancer Gene Therapy
Prodrug activation-based cancer gene therapy is a molecular strategy to improve
2025-03-15 12 -
Electrophoretic Mobility Shift Analysis of the DNA Binding of Tumor Suppressor Gene Products
Central to the tumor suppressor activity of certain proteins is the ability to i
2025-03-15 10 -
Application of SNP Genotype Arrays to Determine Somatic Changes in Cancer
Genetic abnormalities in leukaemia range from single gene defects to chromosomal
2025-03-15 8 -
Detection of K-ras Mutations by a Microelectronic DNA Chip
The increased knowledge of the human genome, thanks to its sequencing and to the
2025-03-15 10 -
Integrating Multiple Clinical Tests to Increase Predictive Power
Clinical tests provide information that can be used by statistical methods to ma
2025-03-15 14
