Less common disorders:E
DISEASE AND CAUSESPATHOPHYSIOLOGYSIGNS AND SYMPTOMSEndocarditisInfection due to
DISEASE AND CAUSES | PATHOPHYSIOLOGY | SIGNS AND SYMPTOMS |
Endocarditis |
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- Infection due to bacteria, viruses, fungi, rickettsiae, and parasites
| Endothelial damage allows microorganisms to adhere to the surface where they proliferate and promote the propagation of endocardial vegetation. | - Weakness and fatigue
- Weight loss, fever, night sweats, and anorexia
- Arthralgia, splenomegaly, and new systolic murmur
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Epidermolysis bullosa |
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- Cause unknown
- Nonscarring forms result from an autosomal dominant inheritance, except for junctional epidermolysis bullosa (recessively inherited) and dystrophic epidermolysis bullosa (results from X-linked recessive inheritance)
| Blisters occur from frictional trauma or heat; prognosis depends on severity. Fatal in infant and child, but becomes less severe as patient matures. | - Blisters appear on hands, feet, knees, or elbows
- Sloughing of large areas of newborn skin
- Blistering occurs in GI, respiratory, or genitourinary tracts
- Eyelid blisters, conjunctivitis, adhesions, and corneal opacities
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Esophageal varices |
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| Shunting of blood to the venae cavae due to portal hypertension leads to dilatation of esophageal veins. | - Hemorrhage and subsequent hypotension
- Compromised oxygen supply
- Altered level of consciousness
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