Organic Acids by Ion Chromatography

The presence of increased levels of various organic acids in physiological fluids such as serum, plasma, and urine has been correlated with a variety of diseases (1 ). Although some are rare, others such as lactic acidosis and hyperoxaluria are more widespread (2 , 3 ). The estimation of organic acids in biological fluids has long been an analytical problem owing to the nature of the samples and the hydrophilic behavior of the various acids.