Roles of Nitric Oxide and Superoxide in Inflammation

Nitric oxide (NO), superoxide, and the product of their reaction peroxynitrite play fundamental roles in inflammation ( see Fig. 1 ). An understanding of the relative contribution of these species to the overall inflammatory response has been achieved by the ability to detect their presence and to block their effects. Fig. 1.  Scheme of Nitric oxide (NO), superoxide and the product of their reaction peroxynitrite formation.