CD71分子

CD71 分子   CD71 常用单克隆抗体或代号： OKT9;(TfR) 主要表达细胞： Mac,增殖细胞 [NL] 分子质量(kDa)和结构： p95(同源二聚体) 功    能：结合白细胞生长   CD71 Aka transferrin receptor Present on actively proliferating cells; essential for iron transport into proliferating cells (benign and malignant) Ferrotransferrin binds CD71 at neutral pH, is internalized to an acidic endosomal compartment Iron-free apotransferrin remains bound to CD71 at pH 5, is returned to cell surface, where pH rises to 7.4. At neutral pH, apotransferrin loses affinity for receptor, is released into circulation, allowing a new cycle to begin Positive staining (normal): all proliferating cells plus iron requiring cells: reticulocytes, erythroid precursors, capillary endothelium in brain Positive staining (disease): AML M6, primary effusion lymphoma