CD64分子

CD64 分子   CD64 常用单克隆抗体或代号： MAb32.2,MAb22;(Fcg RI) 主要表达细胞： M [M] 分子质量(kDa)和结构： gp75(IgSF) 功    能： 吞噬、ADCC,Mac活化   CD64 Aka Fc gamma RI High affinity receptor binds to Fc region of IgG Important in phagocytosis via receptor-mediated endocytosis of IgG-antigen complexes Mediates antigen capture for presentation to T cells, antibody-dependent cellular cytotoxicity, release of cytokines and reactive oxygen intermediates Positive staining (normal): Macrophages/monocytes, activated granulocytes, dendritic cells, early myeloid cells Positive staining (disease): AML M0-M2 (variable); M3 (usually); M4, M5 Negative staining: AML M7