CD31分子

CD31 分子   CD31   常用单克隆抗体或代号： SG134,TM3,HEC- 75;(PECAM、EndoCAM)   主要表达细胞： Pt,M,G,B,NK,Tsub [AS]   分子质量(kDa)和结构： gp140,血小板GPⅡa(IgSF)   功    能： 嗜同性或嗜异性(与CD38互为受体)粘附,炎症,En功能   CD31 Aka platelet endothelial cell adhesion molecule, PECAM-1 Encoded on #17 Most sensitive and specific endothelial marker in paraffin sections Important role in diapedesis step of leukocyte emigration in inflammation; also angiogenesis Note: don’t confuse CD31+ macrophages (granular, membranous expression) with a vascular tumor, AJSP 2001;25:1167 Sensitive for malignant vascular tumors; may be less sensitive for benign lesions Interpretation: membranous stain (not cylasmic); endothelium is a positive internal control Positive staining (normal): endothelium, platelets, macrophages and Kupffer cells, granulocytes, T / NK cells, lymphocytes, megakaryocytes, fibroblasts, osteoclasts, neutrophils Positive staining (tumors): epithelioid hemangioendothelioma; epithelioid sarcoma-like hemangioendothelioma (AJSP 2003;27:48); other vascular tumors, histiocytic malignancies, plasmacytomas; rare carcinomas and sarcomas Micro images: epithelioid angiosarcoma (figure 1A) Micro images (AJSP subscribers): epithelioid sarcoma-like hemangioendothelioma, epithelioid hemangioendothelioma, epithelioid angiosarcoma, CD31+ macrophages, malignant histiocytosis Micro images (Hum Path subscribers): hepatic cavernous hemangiomas (figure 2B) Micro images (Mod Path subscribers): angiosarcoma (figure E) References:  AJSP 2001;25:684, Mod Path 2002:15;434