CD55分子

CD55 分子   CD55 常用单克隆抗体或代号： 143- 30,BRIC110,BRIC123;(DAF) 主要表达细胞： 广泛 [NL] 分子质量(kDa)和结构： gp70(GPI连接) 功    能： 衰变加速因子,调节补体活化   CD55 Aka decay accelerating factor Binds C3bBb (alternative pathway convertase) and C4b2a (classical pathway convertase) to accelerate decay of the C3 convertases; protects against inappropriate complement activation Receptor for CD97 Receptor for echovirus and Coxsackie B virus Deficient in red blood cells from patients with paroxysmal nocturnal hemoglobinuria Positive staining (normal): all hemaoietic cells and all cell types in intimate contact with complement proteins; also epithelial cells lining extracellular compartments, body fluids, extracellular matrix