CD43分子

CD43 分子   CD43 常用单克隆抗体或代号： OTH71C5,G19- 1;(Leukosialin,Sialophorin) 主要表达细胞： T,G,M [NL] 分子质量(kDa)和结构： gp95- 135 功    能： T细胞活化、增殖和粘附,与CD54结合   CD43 Aka leukosialin, sialophorin Appears to be an anti-adhesive molecule mediating repulsion between leukocytes and other cells, although it may act as an adhesion molecule under other circumstances Expression defective in Wiskott-Aldrich syndrome, although secondary to X linked genetic defect; causes defects in cytotoxic and helper T cell functions Positive staining (normal): Most T cells, activated B cells, NK cells, granulocytes, monocytes, megakaryocytes, brain Positive staining (disease): 80% of T cell lymphomas; coexpressed with CD20 in SLL but not benign lesions; granulocytic sarcomas, AML, most ALLs, plasmacytomas; mast cell disease (also positive for tryptase, CD68, CD117) Micro images: granulocytic sarcoma, mantle cell lymphoma Micro images (AJSP subscribers): chronic active myocarditis (figure B)