CD15/CD15s/CD15u分子

CD15/CD15s/CD15u 分子   CD15 常用单克隆抗体或代号： MY1,LeuM1 主要表达细胞： G,(M),RS [AS] 分子质量(kDa)和结构： Lewisx3FAL,X- hapten 功    能： 参与中性粒细胞粘附和吞噬   CD15s 常用单克隆抗体或代号： (唾液酸化CDl5) 主要表达细胞： G,M [AS] 分子质量(kDa)和结构： Sialyl Lewisx(sLex) 功    能： CD62E、CD62L、CD62P配体,白细胞粘附到En和Pt   CDl5u 常用单克隆抗体或代号：  (硫酸化CDl5) 主要表达细胞：  T，NK，En，G，M[CHol 功    能：  参与碳水化合物介导的细胞黏附   CD15 Aka LeuM1, Lacto-N-Fucopentose III ceramide Recognizes Hapten X, a carbohydrate linked to cell membrane proteins of myelomonocytic cells Positive staining (normal): myeloid cells (90%); activated B and T cells (including infectious mononucleosis); eosinophils stain intensely Positive staining (disease): Reed-Sternberg cells, 20% of T cell lymphomas, 5% of B cell lymphomas, 50% of carcinomas Negative staining: erythroid cells, platelets; ALL Micro images: Reed-Sternberg cells-figure 3A, primary pulmonary Hodgkin’s lymphoma-figure 3A   CD15s Aka Sialyl Lewis X; ligand for CD62P and CD62E Positive staining (normal): granulocytes, macrophages 　 CD15u Aka sulfated CD15