CD13分子

CD13 分子   CDl3 常用单克隆抗体或代号：MY7，MOU28 主要表达细胞：M，G，En，Ep[M] 分子质量(kDa)和结构：gp150一170(Ⅱ型膜分子) 功    能：氨肽酶，冠状病毒受体，参与人CMV与靶细胞的结合，抗CDl3自身抗体与GVHD有关   CD13 Aka AminoPeptidase N, APN Myeloid antigen, although CD33 is more specific Peptide cleaving enzyme of brush border membranes of small intestine, renal proximal tubules and placenta Also present on CNS synaptic membranes Receptor for one strain of human coronavirus that causes many upper respiratory tract infections Defects appear to cause various leukemias/lymphomas Serves an important function for early CMV infection CD13 autoantibodies are strongly associated with chronic graft versus host disease after bone marrow transplantation Positive staining (normal): bile duct canaliculi, central nervous system synapses, endothelial cells, fibroblasts, granulocytes (most), large granular lymphocytes (some), macrophages, osteoclasts, perineurium of peripheral nerves, placenta, renal proximal tubules, small intestine Positive staining (disease): AML M1-M5 (75-95%), M6 (usually), CML (90%); pre B ALL (7-10%), pre T ALL (rare)